We recently presented the case of a first century AD young woman, found in the archaeological site of Cosa, showing clinical signs of malnutrition, such as short height, osteoporosis, dental enamel hypoplasia and cribra orbitalia, indirect sign of anemia, all strongly suggestive for celiac disease (CD). However, whether these findings were actually associated to CD was not shown based on genetic parameters. To investigate her human leukocyte antigen (HLA) class II polymorphism, we extracted DNA from a bone sample and a tooth and genotyped HLA using three HLA-tagging single nucleotide polymorphisms for DQ8, DQ2.2 and DQ2.5, specifically associated to CD. She displayed HLA DQ 2.5, the haplotype associated to the highest risk of CD. This is the first report showing the presence of a HLA haplotype compatible for CD in archaeological specimens.
8/9/2013
Origin of celiac disease: How old are predisposing haplotypes?
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Marilyn's Message
2/29/2024
Read moreAddressing Health Equity and Clinical Disparities – Marilyn’s Message February 2024
As we continue our journey toward advancing awareness and understanding of celiac disease, it is crucial that we reflect on health equity and the persistent clinical disparities within our community—so that together we can confront these factors and dismantle barriers hindering access to care and support. Health equity represents the...